Table 2

Comparison of clinical characteristics between LMP1 positive and LMP1 negative patients with IPF

LMP1+ (n=9)LMP1− (n=20)p value
Mean (range) age (years) 56 (38–63)60 (47–72)NS
Sex (M/F)6/316/4NS
Smoking history615NS
Dyspnoea score5.8 (4.2)4.8 (4.1)NS
Clubbing612NS
Radiographic score5.5 (1.0)4.9 (1.2)NS
Laboratory findings at initial examination:
 LDH (IU/l)251 (101)279 (118)NS
 CRP (mg/dl)0.2 (0.2)0.5 (0.7)NS
 Pao 2 (kPa)11.0 (0.9)11.0 (1.5)NS
 %VC (%)73.6 (33.4)79.9 (19.7)NS
Bronchoalveolar lavage cells (%)
 Macrophages91.0 (10.0)82.5 (24.2)NS
 Lymphocytes4.7 (7.5)13.0 (23.7)NS
 Neutrophils6.6 (3.5)5.8 (4.3)NS
 Eosinophils0.5 (1.0)1.9 (4.2)NS
Mean (range) follow up period (mo)42 (12–105)41 (3–98)NS
Steroid treatment6 (67%)5 (25%)<0.05
Outcome
 Died5 (55%)5 (25%)NS
 Cause of death
  Respiratory failure4 (44%)1 (5%)<0.05
  Lung cancer1 (11%)2 (10%)NS
  Pulmonary infection01 (5%)NS
  Heart failure01 (5%)NS
  • LDH = lactate dehydrogenase; CRP = C reactive protein; Pao 2 = arterial oxygen tension; VC = vital capacity.

  • Values are expressed as mean (SD) unless otherwise indicated.