Classification of the more common types of amyloid and amyloidosis
| Type | Fibril precursor protein | Clinical syndrome | |
|---|---|---|---|
| AA | Serum amyloid A protein | Reactive systemic amyloidosis associated with hereditary or acquired chronic inflammatory disease | |
| AL | Monoclonal immunoglobulin light chains; | ||
| Produced systemically | Systemic amyloidosis associated with monoclonal gammopathy, myeloma, etc. | ||
| Produced locally | Amyloidosis localised to the urogenital tract, skin, eyes, respiratory tract, etc. | ||
| ATTR | Normal plasma transthyretin | Senile systemic amyloidosis with prominent cardiac involvement | |
| Genetically variant transthyretin | Autosomal dominant hereditary amyloidosis; familial amyloid polyneuropathy, often with significant cardiac and/or renal amyloidosis | ||
| Aβ2M | β2-microglobulin | Systemic amyloidosis with predominant periarticular involvement associated with renal failure and long term dialysis | |
| Aβ | (β-)amyloid precursor protein | Cerebrovascular and intracerebral plaque amyloid associated with Alzheimer’s disease | |
| AIAPP | Islet amyloid polypeptide | Amyloid in islets of Langerhans in type II diabetes mellitus | |