Mean (95% CI) differences between MRC dyspnoea grade determined by post hoc tests (Fisher’s PLSD)
| Variable | MRC 3 vs MRC 4 | p value | MRC 4 vs MRC 5 | p value |
|---|---|---|---|---|
| SGRQ | ||||
| Activity | 17.1 (8.7 to 25.4) | <0.0001 | ||
| Impact | 16.4 (9.3 to 23.4) | <0.0001 | ||
| CRQ | ||||
| Fatigue | −4.2 (−6.5 to −1.8) | <0.0006 | ||
| Mastery | −6.6 (−8.9 to −4.1) | <0.0001 | ||
| Total | −18.7 (−26.9 to −10.5) | <0.0001 | ||
| HAD | ||||
| Anxiety | 3.0 (0.9 to 4.9) | <0.006 | ||
| Depression | 2.7 (1.4 to 3.9) | <0.0001 | ||
| Age | 5.7 (2.2 to 9.1) | <0.001 | ||
| FVC | −0.4 (−0.8 to 0.09) | <0.02 | ||
SGRQ = St George’s Respiratory Questionnaire; CRQ = Chronic Respiratory Questionnaire; HAD = Hospital Anxiety and Depression score; FVC = forced vital capacity.