Differential bronchoalveolar lavage (BAL) cell counts (% of total cells) in normal (n = 8) and allergic asthmatic (n = 8) subjects four hours after intravenous administration of 144 mg methylprednisolone suleptanate (100 mg methylprednisolone equivalents) and placebo (saline)
Placebo | Methylprednisolone | |
Normal subjects: | ||
Macrophages | 92.1 (87.3–94.4) | 92.7 (79.0–98.0) |
Neutrophils | 0.5 (0.2–1.1) | 1.1 (0.1–4.2) |
Eosinophils | 0.5 (0.2–1.1) | 0.2 (0.0–0.3) |
Lymphocytes | 3.4 (0.6–6.2) | 2.8 (0.9–6.4) |
Epithelial cells | 4.1 (1.3–8.1) | 3.2 (0.7–13.2) |
Asthmatic subjects: | ||
Macrophages | 86.5 (81.7–95.5) | 87.5 (61.0–94.6) |
Neutrophils | 0.7 (0.0–3.3) | 0.6 (0.1–1.4) |
Eosinophils | 0.3 (0.1–0.6) | 0.2 (0.0–1.4) |
Lymphocytes | 2.5 (1.3–6.6) | 3.8 (1.0–5.2) |
Epithelial cells | 5.3 (0.0–14.8) | 10.1 (1.5–37) |
Values are median (range). There were no significant differences between the subject groups in total or differential BAL cell counts after placebo, and methylprednisolone had no significant effect on total or differential BAL cell counts in either subject group.