Table 3

Changes in airway hyperresponsiveness, sputum eosinophil counts, and exhaled NO levels between steroid and placebo treatment groups

Baseline - Week 4Week 4 - Washout
Δ PC20 (mg/ml)
 Steroid2.01 (1.60)–1.75 (1.17)
 Placebo0.19 (0.97)0.17 (1.15)
 95% CI0.483 to 2.034–2.066 to 0.583
 p value0.0030.001
Δ Sputum eosinophils (%)
 Steroid–2.46 (2.52)6.13 (6.37)
 Placebo1.25 (6.30)2.95 (8.48)
 95% CI–8.180 to 0.755 –4.125 to 10.496
 p value0.0980.37
Δ Exhaled NO (ppb)
 Steroid–4.88 (3.13)3.65 (3.60)
 Placebo–1.50 (1.91)1.17 (3.27)
 95% CI–5.571 to –1.175–0.600 to 5.566
 p value0.0050.11
  • Changes in PC20 expressed as geometric mean (SD) in doubling doses; changes in sputum eosinophil counts and exhaled NO levels expressed as mean (SD).