Table 4

Short and long term results of all included studies for forced expiratory volume in one second (FEV1), FEV1 as a percentage of predicted, and six minute walking distance (6MWD) in metres

Study (n)Mean (SD) FEV1Mean (SD) % predicted FEV1Mean (SD) 6MWD
PrePostDifference
(p value)		PrePostDifference
(p value)		PrePostDifference
(p value)
Short term follow up 3–6 months (where studies give results for 3 and 6 months the 6 month results only are presented)
Argenziano24 (66)0.52 (0.19)0.78 (0.38)0.263-152 22 (8)34 (14)123-152 176 (96)273 (96)963-152
Bagley25 (55)3-150 N/AN/A0.19 (0.0002)N/AN/AN/AN/AN/A32 (0.042)
Benditt41(21)1.123-152 1.123-152 0.003-152 243-152 283-152 43-152 N/AN/AN/A
Bousamra26 (45)3-150 0.68 (0.23)0.97 (0.38)0.29 (0.005)26 (9)40 (15)14 (0.002)N/AN/AN/A
Cooper39 (101)3-150 0.703-152 1.063-152 0.36 (<0.001)253-152 383-152 133-152 3383-152 4023-152 64 (<0.001)
Cordova40 (25)3-150 0.68 (0.19)0.93 (0.29)0.25 (<0.001)27 (8)37 (12)103-152 257 (113)338 (80)80 (0.001)
Criner27 (2)0.41 (0.00)0.90 (0.36)0.493-152 38 (1)38 (2.80)03-152 N/AN/AN/A
Daniel28(17)0.733-152 1.023-152 0.29 (<0.0001)253-152 363-152 113-152 N/AN/AN/A
Eugene29 (44)0.41 (0.01)0.62 (0.03)0.213-152 153-152 233-152 83-152 N/AN/AN/A
Eugene30 (25)0.68 (0.05)0.91 (0.35)0.23 (<0.001)N/AN/AN/AN/AN/AN/A
Keller31 (25)3-150 0.80 (0.33)1.05 (0.41)0.25 (<0.001)33 (8.40)35 (7.90)23-152 289 (96)322 (64)32 (0.01)
Kotloff (MS)32 (80)0.73 (0.24)1.02 (0.40)0.293-152 273-152 383-152 113-152 N/AN/AN/A
Kotloff (VATS)32 (40)0.73 (0.24)1.00 (0.37)0.273-152 253-152 363-152 113-152 N/AN/AN/A
Little33 (28)3-150 0.74 (0.07)0.85 (0.06)0.11 (0.009)N/AN/AN/AN/AN/AN/A
McKenna42 (166)0.683-152 0.943-152 0.26 (<0.0001)263-152 363-152 10 (<0.0001)N/AN/AN/A
Miller34(53)0.563-152 1.103-152 0.543-152 243-152 523-152 283-152 2413-152 4823-152 2413-152
Sciurbia35 (20)0.87 (0.36)1.11 (0.45)0.24 (<0.001)32 (11)41 (14)93-152 241 (80)273 (80)32 (0.05)
Snell36 (20)3-150 0.72 (0.19)1.07 (0.30)0.35 (<0.001)28 (6)42 (11)14 (<0.001)306 (129)434 (129)129 (<0.001)
Stammberger37 (42)0.80 (0.24)1.18 (0.44)0.38 (<0.001)29 (7)41 (13)123-152 241 (96)3-151 338 (96)3-151 96 (0.001)3-151
Zenati38(35)0.64 (0.22)0.97 (0.38)0.33 (<0.0001)223-152 353-152 133-152 273 (80)306 (64)32 (<0.05)
IQ range0.64–0.740.91–1.070.23–0.3624–2835–409–13241–290306–43432–96
Long term 1 year follow up
Cooper39(56)3-150 0.693-152 1.003-152 0.313-152 2436123-152 354418643-152
Cordova40 (13)3-150 0.66 (0.17)0.90 (0.35)0.22 (<0.05)N/AN/AN/AN/AN/AN/A
18 months to 2 years follow up
Cooper39(20)3-150 0.833-152 1253-152 0.423-152 2742153-152 370450803-152
Cordova40 (6)3-150 0.69 (0.20)0.91 (0.37)0.22 (<0.12)N/AN/AN/AN/AN/AN/A

  • VATS = video assisted thoracoscopy; MS = median sternotomy; N/A = data not available.

  • ↵3-150 Baseline data appear to have been obtained after pulmonary rehabilitation in the majority of patients.

  • ↵3-151 12MWD halved.

  • ↵3-152 Standard deviations/p value not given.