Renkema7 (bud 1600 μg/bud+pred/plac) | Derenne10(becl 1500 μg/plac) | Kerstjens9 (becl 800 μg/ipra/plac) | |
---|---|---|---|
Original number | Total: 58 (21/19/18) | Total: 194 (100/94) | Total: 51 (19/11/21) |
Meeting inclusion criteria meta-analysis: | |||
Symptoms compatible with diagnosis of COPD | 58 | 194 | 51 |
Age >40 years | 55 | 192 | 39 |
FEV1 post β2agonist < FEV1 pred –1.64SD | 47 | 185 | 29 |
Airway reversibility ⩽ 9% pred FEV1 | 43 | 178 | 29 |
(Ex-)smokers (>0 pack years) | 53 | 173 | 51 |
Not meeting 1 inclusion criterion | 22 | 36 | 25 |
Not meeting 2 inclusion criteria | 6 | 6 | 8 |
Not meeting 3 inclusion criteria | 0 | 0 | 3 |
Not meeting ⩾4 inclusion criteria | 0 | 0 | 0 |
Meeting exclusion criteria meta-analysis: | |||
α1-Antitrypsin deficiency | 0 | 0 | 0 |
Asthma history | 0 | 0 | 0 |
Eligible for meta-analysis | 30 (6/143-150/10) | 152 (81/71) | 15 (8/33-151/4) |