Summary of candidate asthma susceptibility genes
| Chromosomal location | Candidate gene | Function |
|---|---|---|
| 5q31 | IL-3, -4, -5, -9, -13, GM-CSF | Regulators of mast cell, basophil and eosinophil functions |
| 5q32 | β2adrenoreceptor | Bronchodilation |
| 6p | HLA complex | Antigen presentation |
| 6p21.3 | TNFα | Pro-inflammatory pleiotropic cytokine |
| 11q13 | FcεR1 | Signal transduction in mast cells, basophils and dendritic cells |
| 12q | Interferon γ | Inhibition of Th2 cells and IgE switching |
| 12q | Nitric oxide synthase, mast cell growth factor | Inflammatory mediators |
| 13q | Esterase D | |
| 14q | TCR α/γ complex | T cell activation |
Reproduced from reference 5 with permission.