Streptomycin | | 15 mg/kg | 15 mg/kg (max dose 1 g daily) | Tinnitus, ataxia, vertigo, renal impairment |
Amikacin | | 15 mg/kg | 15 mg/kg | As for streptomycin |
Capreomycin | | | 15 mg/kg | As for streptomycin |
Kanamycin | | | 15 mg/kg | As for streptomycin |
|
Ethionamide or prothionamide | | 15–20 mg/kg | <50 kg, 375 mg bd | Gastrointestinal; hepatitis; avoid in pregnancy |
| | ⩾50 kg, 500 mg bd | |
|
Cycloserine | | | 250–500 mg bd | Depression: fits |
|
Ofloxacin | | | 400 mg bd | Abdominal distress, headache, tremulousness |
Ciprofloxacin | | | 750 mg bd | As ofloxacin plus drug interactions |
| | | | |
Azithromycin | | | 500 mg | Gastrointestinal upset |
Clarithromycin | | | 500 mg bd | As for azithromycin |
| | | | |
Rifabutin | | | 300–450 mg | As for rifampicin; uveitis can occur with drug interactions e.g. macrolides. Often cross resistance with rifampicin |
| | | | |
Thiacetazone | | 4 mg/kg | 150 mg | Gastrointestinal, vertigo, conjunctivitis, rash. AVOID if HIV positive (Stevens-Johnson syndrome) |
| | | | |
Clofazimine | | | 300 mg | Headache, diarrhoea, red skin discolouration |
| | | | |
PAS sodium | | 300 mg/kg | 10 g om or 5 g bd | Gastrointestinal, hepatitis, fever, rash |