Pathological diagnosis | ARDS aetiology | Mechanical ventilation (days) | Tissue source |
---|---|---|---|
ARDS: early stage (ARDS (E)) | |||
Exudative DAD | Neurogenic pulmonary oedema/hypotension | 1 | Necropsy |
Exudative DAD | Sepsis | 3 | Necropsy |
Exudative DAD | Sepsis/aspiration | 4 | Necropsy |
Exudative DAD | Sepsis/hypotension | 6 | Necropsy |
Exudative DAD | Pneumonia | 7 | Necropsy |
Exudative DAD | Pneumonia | 7 | Necropsy |
ARDS: reparative stage (ARDS (R)) | |||
Mixed/organising DAD | Pneumonia suspected | 2 | Open lung biopsy |
Mixed/organising DAD | Shock/cardiopulmonary bypass | 4 | Necropsy |
Mixed/organising DAD | Pneumonia | 5 | Open lung biopsy |
Mixed/organising DAD | Miscellaneous | 9 | Necropsy |
Mixed/organising DAD | Pneumonia | 9 | Necropsy |
Mixed/organising DAD | Sepsis | 34 | Necropsy |
Fibroproliferative DAD | Pneumonia suspected | 12 | Open lung biopsy |
Fibroproliferative DAD | Pneumonia/aspiration | 15 | Necropsy |
Fibroproliferative DAD | Hypotension/sepsis | 15 | Necropsy |
Fibroproliferative DAD | Sepsis | 23 | Necropsy |
Fibroproliferative DAD | Heat stroke/hypotension | 30 | Necropsy |
Normal tissue | |||
Normal | N/A | N/A | Surgical specimen |
Normal | N/A | N/A | Necropsy |
Normal | N/A | N/A | Necropsy |
Fibrotic lung tissue | |||
IPF | N/A | N/A | Open lung biopsy |
IPF | N/A | N/A | Lung removed for transplant |
IPF | N/A | N/A | Lung removed for transplant |
IPF | N/A | N/A | Lung removed for transplant |
DAD = diffuse alveolar damage; IPF = idiopathic pulmonary fibrosis (all samples demonstrated end stage lung disease); mechanical ventilation = days on mechanical ventilation before lung tissue obtained; N/A = not applicable.