Cystic fibrosis | Controls | p Value | |
Subjects (n) | 25 | 25 | – |
Age, years (range) | 14±4 (8–20) | 14±4 (7–20) | 0.77 |
Male (n) | 15 | 15 | 1.00 |
BMI z-score | 0.1±0.9 | 0.4±0.8 | 0.32 |
Epworth Sleepiness Scale | 5±4 | NA | – |
Pulmonary function parameters | |||
Forced vital capacity (FVC), % predicted | 99±12 | NA | – |
Forced expiratory volume in 1 s (FEV1), % predicted | 92±14 | NA | – |
FEV1/FVC (%) | 81±9 | NA | – |
Polysomnographic parameters | |||
Total recording time, min | 522±75 | 510±30 | 0.74 |
Sleep efficiency, % TST | 78±13 | 83±13 | 0.13 |
Total sleep time, min | 383±62 | 412±69 | 0.13 |
Wake after sleep onset, min | 83±68 | 55±51 | 0.11 |
Sleep latency, min | 31±32 | 27±18 | 0.57 |
Latency to REM, min | 128±71 | 132±74 | 0.82 |
Stage N1, % TST | 9±4 | 7±4 | 0.10 |
Stage N2, % TST | 50±8 | 53±7 | 0.20 |
Stage N3, % TST | 22±10 | 22±8 | 0.85 |
REM, % TST | 19±5 | 18±5 | 0.73 |
Arousal index, N/h | 16±5 | 11±4 | <0.001 |
Obstructive apnea index, N/h | 0.0 (0.0, 0.6) | 0.0 (0.0, 0.2) | 0.13 |
Hypopnoea index, N/h | 0.4 (0.0, 6.0) | 0.0 (0.0, 0.9) | 0.066 |
SpO2 mean, % | 96.6±1.0 | 97.5±0.7 | <0.001 |
SpO2 nadir, % | 92.5±2.2 | 93.8±1.9 | 0.031 |
Time with SpO2 <92%, % TST | 0.0 (0.0, 6.7) | 0.0 (0.0, 0.2) | 0.11 |
TcCO2 mean, mm Hg | 47.8±6.8 | NA | – |
Periodic limb movement index, N/h | 0.0 (0.0, 22.8) | 0.0 (0.0, 8.7) | 0.32 |
Data are presented as mean±SD for normally distributed variables and median (range) for skewed variables.
BMI, body mass index; NA, not available; REM, rapid eye movement sleep; TcCO2, transcutaneous CO2; TST, total sleep time.