Table 1

Studies in human subjects showing (+) and not showing (−) significant correlations between airway inflammation and airway hyperresponsiveness

AuthorsYearAssessmentMarker(s)
BALBBSputum
Kirby et al 91 1987+Eos
Wardlawet al 92 1988+Eos, MBP
Kelly et al 93 1988−Eos
Chan Yeunget al 94 1988−Eos
Pliss et al 95 1989+Eos
Jeffery et al 96 1989−Eos
Fergusonet al 97 1989+Eos
Gibsonet al 98 1989−Eos
Djukanovic et al 99 1990−EG2
Brusascoet al 72 1990−Eos
Foresi et al 100 1990−−Eos
Adelrothet al 101 1-150 1990−Eos, ECP
Bradley et al 60 1991+EG2
Walker et al 102 1991+Eos
Bentleyet al 103 1992+EG2
Ollerenshaw et al 104 1992−Eos
Fergusonet al 105 1992±Eos, ECP
Pin et al 106 1993+Eos
Duddridge et al 107 1-150 1993−Eos
Iredaleet al 108 1994−Eos
Woolley et al 109 1996++EG2, Eos
Chettaet al 110 1996+Eos
Kidney et al 111 1996−Eos
Pizzichiniet al 112 1996+Eos, MBP
Foresi et al 113 1997+EG2
Crimi et al 114 1998−−−Eos, ECP

  • BAL = bronchoalveolar lavage; BB = bronchial biopsy; Eos = number or percentage of eosinophils; ECP = eosinophil cationic protein; MBP = major basic protein; EG2 = cells stained with anti-ECP antibodies.

  • ↵1-150 With anti-inflammatory treatment.