Table 2

Gene therapy for cystic fibrosis

Inefficient gene deliveryImproved vectors and delivery devices
Inflammatory response to vectorEngineering and formulation of viral vectors and liposomes
Lack of cell specific targetingViral subtypes
Receptor mediated cell targeting
Transient expressionEpisomal maintenance
Safe site integration
Transfect stem cells
Non-physiological expressionGenomic context vectors
Cell specific expression