RT Journal Article
SR Electronic
T1 Rate advancement measurement for lung cancer and pleural mesothelioma in asbestos-exposed workers
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP thoraxjnl-2021-217862
DO 10.1136/thorax-2021-217862
A1 Azzolina, Danila
A1 Consonni, Dario
A1 Ferrante, Daniela
A1 Mirabelli, Dario
A1 Silvestri, Stefano
A1 Luberto, Ferdinando
A1 Angelini, Alessia
A1 Cuccaro, Francesco
A1 Nannavecchia, Anna Maria
A1 Oddone, Enrico
A1 Vicentini, Massimo
A1 Barone-Adesi, Francesco
A1 Cena, Tiziana
A1 Mangone, Lucia
A1 Roncaglia, Francesca
A1 Sala, Orietta
A1 Menegozzo, Simona
A1 Pirastu, Roberta
A1 Tunesi, Sara
A1 Chellini, Elisabetta
A1 Miligi, Lucia
A1 Perticaroli, Patrizia
A1 Pettinari, Aldo
A1 Bressan, Vittoria
A1 Merler, Enzo
A1 Girardi, Paolo
A1 Bisceglia, Lucia
A1 Marinaccio, Alessandro
A1 Massari, Stefania
A1 Magnani, Corrado
A1 ,
YR 2022
UL http://thorax.bmj.com/content/early/2022/12/07/thorax-2021-217862.abstract
AB Introduction Exposure to asbestos increases the risk of lung cancer and mesothelioma. Few studies quantified the premature occurrence of these diseases in asbestos-exposed workers. Focus on premature disease onset (rate advancement or acceleration) can be useful in risk communication and for the evaluation of exposure impact. We estimated rate advancement for total mortality, lung cancer and pleural mesothelioma deaths, by classes of cumulative asbestos exposure in a pooled cohort of asbestos cement (AC) workers in Italy.Method The cohort study included 12 578 workers from 21 cohorts, with 6626 deaths in total, 858 deaths from lung cancer and 394 from pleural malignant neoplasm (MN). Rate advancement was estimated by fitting a competitive mortality Weibull model to the hazard of death over time since first exposure (TSFE).Result Acceleration time (AT) was estimated at different TSFE values. The highest level of cumulative exposure compared with the lowest, for pleural MN AT was 16.9 (95% CI 14.9 to 19.2) and 33.8 (95% CI 29.8 to 38.4) years at TSFE of 20 and 40 years, respectively. For lung cancer, it was 13.3 (95% CI 12.0 to 14.7) and 26.6 (95% CI 23.9 to 29.4) years, respectively. As for total mortality, AT was 3.35 (95% CI 2.98 to 3.71) years at 20 years TSFE, and 6.70 (95% CI 5.95 to 7.41) at 40 years TSFE.Conclusion The current study observed marked rate advancement after asbestos exposure for lung cancer and pleural mesothelioma, as well as for total mortality.Data are available on reasonable request.