TY - JOUR T1 - Rebound in asthma exacerbations following relaxation of COVID-19 restrictions: a longitudinal population-based study (COVIDENCE UK) JF - Thorax JO - Thorax DO - 10.1136/thorax-2022-219591 SP - thorax-2022-219591 AU - Florence Tydeman AU - Paul E Pfeffer AU - Giulia Vivaldi AU - Hayley Holt AU - Mohammad Talaei AU - David Jolliffe AU - Gwyneth Davies AU - Ronan A Lyons AU - Christopher Griffiths AU - Frank Kee AU - Aziz Sheikh AU - Seif O Shaheen AU - Adrian R Martineau Y1 - 2022/11/24 UR - http://thorax.bmj.com/content/early/2022/11/23/thorax-2022-219591.abstract N2 - Background The imposition of restrictions on social mixing early in the COVID-19 pandemic was followed by a reduction in asthma exacerbations in multiple settings internationally. Temporal trends in social mixing, incident acute respiratory infections (ARI) and asthma exacerbations following relaxation of COVID-19 restrictions have not yet been described.Methods We conducted a population-based longitudinal study in 2312 UK adults with asthma between November 2020 and April 2022. Details of face covering use, social mixing, incident ARI and severe asthma exacerbations were collected via monthly online questionnaires. Temporal changes in these parameters were visualised using Poisson generalised additive models. Multilevel logistic regression was used to test for associations between incident ARI and risk of asthma exacerbations, adjusting for potential confounders.Results Relaxation of COVID-19 restrictions from April 2021 coincided with reduced face covering use (p<0.001), increased frequency of indoor visits to public places and other households (p<0.001) and rising incidence of COVID-19 (p<0.001), non-COVID-19 ARI (p<0.001) and severe asthma exacerbations (p=0.007). Incident non-COVID-19 ARI associated independently with increased risk of asthma exacerbation (adjusted OR 5.75, 95% CI 4.75 to 6.97) as did incident COVID-19, both prior to emergence of the omicron variant of SARS-CoV-2 (5.89, 3.45 to 10.04) and subsequently (5.69, 3.89 to 8.31).Conclusions Relaxation of COVID-19 restrictions coincided with decreased face covering use, increased social mixing and a rebound in ARI and asthma exacerbations. Associations between incident ARI and risk of severe asthma exacerbation were similar for non-COVID-19 ARI and COVID-19, both before and after emergence of the SARS-CoV-2 omicron variant.Study registration number NCT04330599.Deidentified participant data are available from the corresponding author (a.martineau@qmul.ac.uk) on reasonable request, subject to the terms of Research Ethics Committee approval. ER -