TY - JOUR T1 - International differences in lung cancer survival by sex, histological type and stage at diagnosis: an ICBP SURVMARK-2 Study JF - Thorax JO - Thorax SP - 378 LP - 390 DO - 10.1136/thoraxjnl-2020-216555 VL - 77 IS - 4 AU - Marzieh Araghi AU - Miranda Fidler-Benaoudia AU - Melina Arnold AU - Mark Rutherford AU - Aude Bardot AU - Jacques Ferlay AU - Oliver Bucher AU - Prithwish De AU - Gerda Engholm AU - Anna Gavin AU - Serena Kozie AU - Alana Little AU - Bjørn Møller AU - Nathalie St Jacques AU - Hanna Tervonen AU - Paul Walsh AU - Ryan Woods AU - Dianne L O'Connell AU - David Baldwin AU - Mark Elwood AU - Sabine Siesling AU - Freddie Bray AU - Isabelle Soerjomataram AU - ICBP SURVMARK-2 Local Leads AU - ICBP SURVMARK-2 Academic Reference Group A2 - , Y1 - 2022/04/01 UR - http://thorax.bmj.com/content/77/4/378.abstract N2 - Introduction Lung cancer has a poor prognosis that varies internationally when assessed by the two major histological subgroups (non-small cell (NSCLC) and small cell (SCLC)).Method 236 114 NSCLC and 43 167 SCLC cases diagnosed during 2010–2014 in Australia, Canada, Denmark, Ireland, New Zealand, Norway and the UK were included in the analyses. One-year and 3-year age-standardised net survival (NS) was estimated by sex, histological type, stage and country.Results One-year and 3-year NS was consistently higher for Canada and Norway, and lower for the UK, New Zealand and Ireland, irrespective of stage at diagnosis. Three-year NS for NSCLC ranged from 19.7% for the UK to 27.1% for Canada for men and was consistently higher for women (25.3% in the UK; 35.0% in Canada) partly because men were diagnosed at more advanced stages. International differences in survival for NSCLC were largest for regional stage and smallest at the advanced stage. For SCLC, 3-year NS also showed a clear female advantage with the highest being for Canada (13.8% for women; 9.1% for men) and Norway (12.8% for women; 9.7% for men).Conclusion Distribution of stage at diagnosis among lung cancer cases differed by sex, histological subtype and country, which may partly explain observed survival differences. Yet, survival differences were also observed within stages, suggesting that quality of treatment, healthcare system factors and prevalence of comorbid conditions may also influence survival. Other possible explanations include differences in data collection practice, as well as differences in histological verification, staging and coding across jurisdictions.Data may be obtained from a third party and are not publicly available. Data contain sensitive and personal information and can be obtained from the cancer registries listed as the local leads in the manuscript. ER -