RT Journal Article
SR Electronic
T1 Exposure to inorganic particles in paediatric sarcoidosis: the PEDIASARC study
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 404
OP 407
DO 10.1136/thoraxjnl-2021-217870
VO 77
IS 4
A1 Nathan, Nadia
A1 Montagne, Marie-Emeline
A1 Macchi, Odile
A1 Rosental, Paul-André
A1 Chauveau, Simon
A1 Jeny, Florence
A1 Sesé, Lucile
A1 Abou Taam, Rola
A1 Brocvielle, Manon
A1 Brouard, Jacques
A1 Catinon, Mickaël
A1 Chapelon-Abric, Catherine
A1 Cohen-Aubart, Fleur
A1 Delacourt, Christophe
A1 Delestrain, Céline
A1 Deschildre, Antoine
A1 Dossier, Antoine
A1 Epaud, Ralph
A1 Haroche, Julien
A1 Houdouin, Véronique
A1 Israel-Biet, Dominique
A1 Juvin, Karine
A1 Le Jeune, Sylvain
A1 Lionnet, Francois
A1 Meinzer, Ulrich
A1 Mittaine, Marie
A1 Nunes, Hilario
A1 Mattioni, Sarah
A1 Naccache, Jean-Marc
A1 Odièvre, Marie-Hélène
A1 Vincent, Michel
A1 Clement, Annick
A1 Valeyre, Dominique
A1 Cavalin, Catherine
YR 2022
UL http://thorax.bmj.com/content/77/4/404.abstract
AB Inorganic antigens may contribute to paediatric sarcoidosis. Thirty-six patients matched with 36 healthy controls as well as a group of 21 sickle-cell disease (SCD) controls answered an environmental questionnaire. Patients’ indirect exposure to inorganic particles, through coresidents’ occupations, was higher than in healthy and SCD controls (median score: 2.5 (0.5–7) vs 0.5 (0–2), p=0.003 and 1 (0–2), p=0.012, respectively), especially for construction, exposures to metal dust, talc, abrasive reagents and scouring products. Wood or fossil energies heating were also linked to paediatric sarcoidosis. This study supports a link between mineral environmental exposure due to adult coresident occupations and paediatric sarcoidosis.