PT  - JOURNAL ARTICLE
AU  - Simon Couillard
AU  - Annette Laugerud
AU  - Maisha Jabeen
AU  - Sanjay Ramakrishnan
AU  - James Melhorn
AU  - Timothy Hinks
AU  - Ian Pavord
TI  - Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide
AID  - 10.1136/thoraxjnl-2021-217325
DP  - 2022 Feb 01
TA  - Thorax
PG  - 199--202
VI  - 77
IP  - 2
4099  - http://thorax.bmj.com/content/77/2/199.short
4100  - http://thorax.bmj.com/content/77/2/199.full
SO  - Thorax2022 Feb 01; 77
AB  - Reduction of the risk of asthma attacks is a major goal of current asthma management. We propose to derive a risk scale predicting asthma attacks based on the blood eosinophil count and exhaled nitric oxide (FeNO). Biomarker-stratified trial-level attack rates were extracted and pooled from the control arms of the Novel START, CAPTAIN, QUEST, Benralizumab Phase 2b, PATHWAY, STRATOS 1–2 and DREAM trials (n=3051). These were used to derive rate ratios and the predicted asthma attack rate for different patient groups. The resultant prototype risk scale shows potential to predict asthma attacks, which may be prevented by anti-inflammatory treatment.