RT Journal Article
SR Electronic
T1 Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 186
OP 190
DO 10.1136/thoraxjnl-2021-217315
VO 77
IS 2
A1 Whalen, William
A1 Buyukozkan, Mustafa
A1 Moore, Bethany
A1 Moon, Jong-Seok
A1 Dela Cruz, Charles S
A1 Martinez, Fernando J
A1 Choi, Augustine M K
A1 Krumsiek, Jan
A1 Stout-Delgado, Heather
A1 Cho, Soo Jung
YR 2022
UL http://thorax.bmj.com/content/77/2/186.abstract
AB Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with unclear aetiology and poorly understood pathophysiology. Although plasma levels of circulating cell-free DNA (ccf-DNA) and metabolomic changes have been reported in IPF, the associations between ccf-DNA levels and metabolic derangements in lung fibrosis are unclear. Here, we demonstrate that ccf-double-stranded DNA (dsDNA) is increased in patients with IPF with rapid progression of disease compared with slow progressors and healthy controls and that ccf-dsDNA associates with amino acid metabolism, energy metabolism and lipid metabolism pathways in patients with IPF.