RT Journal Article SR Electronic T1 Secondhand nicotine vaping at home and respiratory symptoms in young adults JF Thorax JO Thorax FD BMJ Publishing Group Ltd and British Thoracic Society SP thoraxjnl-2021-217041 DO 10.1136/thoraxjnl-2021-217041 A1 Talat Islam A1 Jessica Braymiller A1 Sandrah P Eckel A1 Feifei Liu A1 Alayna P Tackett A1 Meghan E Rebuli A1 Jessica Barrington-Trimis A1 Rob McConnell YR 2022 UL http://thorax.bmj.com/content/early/2022/01/05/thoraxjnl-2021-217041.abstract AB Rationale Despite high prevalence of e-cigarette use (vaping), little is currently known regarding the health effects of secondhand nicotine vape exposure.Objective To investigate whether exposure to secondhand nicotine vape exposure is associated with adverse respiratory health symptoms among young adults.Method We investigated the effect of secondhand nicotine vape exposure on annually reported wheeze, bronchitic symptoms and shortness of breath in the prospective Southern California Children Health Study cohort. Data were collected from study participants (n=2097) with repeated annual surveys from 2014 (average age: 17.3 years) to 2019 (average age: 21.9). We used mixed effect logistic regression to evaluate the association between secondhand nicotine vape and respiratory symptoms after controlling for relevant confounders.Results Prevalence of secondhand nicotine vape increased from 11.7% to 15.6% during the study period in this population. Prevalence of wheeze, bronchitic symptoms and shortness of breath ranged from 12.3% to 14.9%, 19.4% to 26.0% and 16.5% to 18.1%, respectively, during the study period. Associations of secondhand nicotine vape exposure with bronchitic symptoms (OR 1.40, 95% CI 1.06 to 1.84) and shortness of breath (OR 1.53, 95% CI 1.06 to 2.21) were observed after controlling for vaping, active and passive exposure to tobacco or cannabis, and demographic characteristics (age, gender, race/ethnicity and parental education). Stronger associations were observed when analysis was restricted to participants who were neither smokers nor vapers. There were no associations with wheezing after adjustment for confounders.Conclusion Secondhand nicotine vape exposure was associated with increased risk of bronchitic symptoms and shortness of breath among young adults.No data are available, however, data might be requested through USC TCORS.