RT Journal Article
SR Electronic
T1 Pulmonary fibrosis 4 months after COVID-19 is associated with severity of illness and blood leucocyte telomere length
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 1242
OP 1245
DO 10.1136/thoraxjnl-2021-217031
VO 76
IS 12
A1 Claire F McGroder
A1 David Zhang
A1 Mohammad A Choudhury
A1 Mary M Salvatore
A1 Belinda M D'Souza
A1 Eric A Hoffman
A1 Ying Wei
A1 Matthew R Baldwin
A1 Christine Kim Garcia
YR 2021
UL http://thorax.bmj.com/content/76/12/1242.abstract
AB The risk factors for development of fibrotic-like radiographic abnormalities after severe COVID-19 are incompletely described and the extent to which CT findings correlate with symptoms and physical function after hospitalisation remains unclear. At 4 months after hospitalisation, fibrotic-like patterns were more common in those who underwent mechanical ventilation (72%) than in those who did not (20%). We demonstrate that severity of initial illness, duration of mechanical ventilation, lactate dehydrogenase on admission and leucocyte telomere length are independent risk factors for fibrotic-like radiographic abnormalities. These fibrotic-like changes correlate with lung function, cough and measures of frailty, but not with dyspnoea.