RT Journal Article SR Electronic T1 Nasal versus oronasal masks for home non-invasive ventilation in patients with chronic hypercapnia: a systematic review and individual participant data meta-analysis JF Thorax JO Thorax FD BMJ Publishing Group Ltd and British Thoracic Society SP 1108 OP 1116 DO 10.1136/thoraxjnl-2020-215613 VO 76 IS 11 A1 Marius Lebret A1 Antoine Léotard A1 Jean Louis Pépin A1 Wolfram Windisch A1 Emelie Ekkernkamp A1 Mercedes Pallero A1 M-Ángeles Sánchez-Quiroga A1 Nicholas Hart A1 Julia L Kelly A1 Maxime Patout A1 Georg Chistian Funk A1 Marieke L Duiverman A1 Juan F Masa A1 Anita Simonds A1 Patrick Brian Murphy A1 Peter J Wijkstra A1 Michael Dreher A1 Jan Storre A1 Charles Khouri A1 Jean-Christian Borel YR 2021 UL http://thorax.bmj.com/content/76/11/1108.abstract AB Background The optimal interface for the delivery of home non-invasive ventilation (NIV) to treat chronic respiratory failure has not yet been determined. The aim of this individual participant data (IPD) meta-analysis was to compare the effect of nasal and oronasal masks on treatment efficacy and adherence in patients with COPD and obesity hypoventilation syndrome (OHS).Methods We searched Medline and Cochrane Central Register of Controlled Trials for prospective randomised controlled trials (RCTs) of at least 1 month’s duration, published between January 1994 and April 2019, that assessed NIV efficacy in patients with OHS and COPD. The main outcomes were diurnal PaCO2, PaO2 and NIV adherence (PROSPERO CRD42019132398).Findings Of 1576 articles identified, 34 RCTs met the inclusion criteria and IPD were obtained for 18. Ten RCTs were excluded because only one type of mask was used, or mask data were missing. Data from 8 RCTs, including 290 IPD, underwent meta-analysis. Oronasal masks were used in 86% of cases. There were no differences between oronasal and nasal masks for PaCO2 (0.61 mm Hg (95% CI −2.15 to 3.38); p=0.68), PaO2 (−0.00 mm Hg (95% CI −4.59 to 4.58); p=1) or NIV adherence (0·29 hour/day (95% CI −0.74 to 1.32); p=0.58). There was no interaction between the underlying pathology and the effect of mask type on any outcome.Interpretation Oronasal masks are the most used interface for the delivery of home NIV in patients with OHS and COPD; however, there is no difference in the efficacy or tolerance of oronasal or nasal masks.No data are available. All of the anonymised individual participant data collected in this systematic review and meta-analyisis must be asked to each authors individually.