PT  - JOURNAL ARTICLE
AU  - Raúl Méndez
AU  - Paula González-Jiménez
AU  - Ana Latorre
AU  - Mónica Piqueras
AU  - Leyre Bouzas
AU  - Katheryn Yépez
AU  - Ana Ferrando
AU  - Enrique Zaldívar-Olmeda
AU  - Antonio Moscardó
AU  - Ricardo Alonso
AU  - Soledad Reyes
AU  - Rosario Menéndez
TI  - Acute and sustained increase in endothelial biomarkers in COVID-19
AID  - 10.1136/thoraxjnl-2020-216797
DP  - 2021 Oct 03
TA  - Thorax
PG  - thoraxjnl-2020-216797
4099  - http://thorax.bmj.com/content/early/2021/10/03/thoraxjnl-2020-216797.short
4100  - http://thorax.bmj.com/content/early/2021/10/03/thoraxjnl-2020-216797.full
AB  - Endothelial injury is related to poor outcomes in respiratory infections yet little is known in relation to COVID-19. Performing a longitudinal analysis (on emergency department admission and post-hospitalisation follow-up), we evaluated endothelial damage via surrogate systemic endothelial biomarkers, that is, proadrenomedullin (proADM) and proendothelin, in patients with COVID-19. Higher proADM and/or proendothelin levels at baseline were associated with the most severe episodes and intensive care unit admission when compared with ward-admitted individuals and outpatients. Elevated levels of proADM or proendothelin at day 1 were associated with in-hospital mortality. High levels maintained after discharge were associated with reduced diffusing capacity.