PT  - JOURNAL ARTICLE
AU  - Nicola Latronico
AU  - Elena Peli
AU  - Stefano Calza
AU  - Federica Rodella
AU  - Maria Paola Novelli
AU  - Andrea Cella
AU  - John Marshall
AU  - Dale M Needham
AU  - Frank Antony Rasulo
AU  - Simone Piva
ED  - ,
TI  - Physical, cognitive and mental health outcomes in 1-year survivors of COVID-19-associated ARDS
AID  - 10.1136/thoraxjnl-2021-218064
DP  - 2021 Sep 29
TA  - Thorax
PG  - thoraxjnl-2021-218064
4099  - http://thorax.bmj.com/content/early/2021/09/29/thoraxjnl-2021-218064.short
4100  - http://thorax.bmj.com/content/early/2021/09/29/thoraxjnl-2021-218064.full
AB  - We report on the outcome of 114 COVID-19-associated acute respiratory distress syndrome (ARDS) survivors evaluated at 3, 6 and 12 months after intensive care unit discharge with assessment of physical, mental and cognitive impairments. Critical illness polyneuromyopathy was diagnosed in 23 patients (39%). Handgrip dynamometry was 70% predicted at 3 months and significantly improved over time, whereas the 6 min walk test (80% predicted) and severe fatigue (27% of patients) did not. Independence in activities of daily living (ADL) was achieved by 98% at 3 months. Cognitive impairment (28% at 3 months) improved over time, whereas depression, anxiety and post-traumatic stress disorder symptoms, present in 9%, 10% and 4% at 3 months, did not. Normalised health-related quality of life was good. COVID-19-associated ARDS leads to persisting impairment in performance-based measures of physical function, while ADL, cognitive and mental health status, and health-related quality of life may be less impaired. Trial registration number NCT04608994.