TY - JOUR T1 - Physical, cognitive and mental health outcomes in 1-year survivors of COVID-19-associated ARDS JF - Thorax JO - Thorax DO - 10.1136/thoraxjnl-2021-218064 SP - thoraxjnl-2021-218064 AU - Nicola Latronico AU - Elena Peli AU - Stefano Calza AU - Federica Rodella AU - Maria Paola Novelli AU - Andrea Cella AU - John Marshall AU - Dale M Needham AU - Frank Antony Rasulo AU - Simone Piva A2 - , Y1 - 2021/09/29 UR - http://thorax.bmj.com/content/early/2021/09/29/thoraxjnl-2021-218064.abstract N2 - We report on the outcome of 114 COVID-19-associated acute respiratory distress syndrome (ARDS) survivors evaluated at 3, 6 and 12 months after intensive care unit discharge with assessment of physical, mental and cognitive impairments. Critical illness polyneuromyopathy was diagnosed in 23 patients (39%). Handgrip dynamometry was 70% predicted at 3 months and significantly improved over time, whereas the 6 min walk test (80% predicted) and severe fatigue (27% of patients) did not. Independence in activities of daily living (ADL) was achieved by 98% at 3 months. Cognitive impairment (28% at 3 months) improved over time, whereas depression, anxiety and post-traumatic stress disorder symptoms, present in 9%, 10% and 4% at 3 months, did not. Normalised health-related quality of life was good. COVID-19-associated ARDS leads to persisting impairment in performance-based measures of physical function, while ADL, cognitive and mental health status, and health-related quality of life may be less impaired. Trial registration number NCT04608994. ER -