RT Journal Article
SR Electronic
T1 Maternal asthma is associated with reduced lung function in male infants in a combined analysis of the BLT and BILD cohorts
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 996
OP 1001
DO 10.1136/thoraxjnl-2020-215526
VO 76
IS 10
A1 de Gouveia Belinelo, Patricia
A1 Collison, Adam M
A1 Murphy, Vanessa E
A1 Robinson, Paul D
A1 Jesson, Kathryn
A1 Hardaker, Kate
A1 de Queiroz Andrade, Ediane
A1 Oldmeadow, Christopher
A1 Martins Costa Gomes, Gabriela
A1 Sly, Peter D
A1 Usemann, Jakob
A1 Appenzeller, Rhea
A1 Gorlanova, Olga
A1 Fuchs, Oliver
A1 Latzin, Philipp
A1 Gibson, Peter G
A1 Frey, Urs
A1 Mattes, Joerg
YR 2021
UL http://thorax.bmj.com/content/76/10/996.abstract
AB Rationale Asthma in pregnancy is associated with respiratory diseases in the offspring.Objective To investigate if maternal asthma is associated with lung function in early life.Methods Data on lung function measured at 5–6 weeks of age were combined from two large birth cohorts: the Bern Infant Lung Development (BILD) and the Australian Breathing for Life Trial (BLT) birth cohorts conducted at three study sites (Bern, Switzerland; Newcastle and Sydney, Australia). The main outcome variable was time to reach peak tidal expiratory flow as a percentage of total expiratory time(tPTEF:tE%). Bayesian linear hierarchical regression analyses controlling for study site as random effect were performed to estimate the effect of maternal asthma on the main outcome, adjusting for sex, birth order, breast feeding, weight gain and gestational age. In separate adjusted Bayesian models an interaction between maternal asthma and sex was investigated by including an interaction term.Measurements and main results All 406 BLT infants were born to mothers with asthma in pregnancy, while 193 of the 213 (91%) BILD infants were born to mothers without asthma. A significant interaction between maternal asthma and male sex was negatively associated with tPTEF:tE% (intercept 37.5; estimate: –3.5; 95% credible interval –6.8 to –0.1). Comparing the model posterior probabilities provided decisive evidence in favour of an interaction between maternal asthma and male sex (Bayes factor 33.5).Conclusions Maternal asthma is associated with lower lung function in male babies, which may have lifelong implications on their lung function trajectories and future risk of wheezing and asthma.Data are available upon reasonable request.