TY - JOUR T1 - Association between lung function of school age children and short-term exposure to air pollution and pollen: the PARIS cohort JF - Thorax JO - Thorax SP - 887 LP - 894 DO - 10.1136/thoraxjnl-2020-215515 VL - 76 IS - 9 AU - Hélène Amazouz AU - Nicolas Bougas AU - Michel Thibaudon AU - Guillaume Lezmi AU - Nicole Beydon AU - Mélisande Bourgoin-Heck AU - Jocelyne Just AU - Isabelle Momas AU - Fanny Rancière Y1 - 2021/09/01 UR - http://thorax.bmj.com/content/76/9/887.abstract N2 - Background Daily levels of ambient air pollution and pollen may affect lung function but have rarely been studied together. We investigated short-term exposure to pollen and air pollution in relation to lung function in school-age children from a French population-based birth cohort.Methods This study included 1063 children from the PARIS (Pollution and Asthma Risk: an Infant Study) cohort whose lung function and FeNO measurements were performed at age 8 years old. Exposure data were collected up to 4 days before testing. We estimated daily total pollen concentration, daily allergenic risk indices for nine pollen taxa, as well as daily concentrations of three air pollutants (particulate matter less than 10 µm (PM10), nitrogen dioxide (NO2), ozone (O3)). Children with similar pollen and air pollution exposure were grouped using multidimensional longitudinal cluster analysis. Associations between clusters of pollen and air pollution exposure and respiratory indices (FEV1, FVC, FeNO) were studied using multivariable linear and logistic regression models adjusted for potential confounders.Results Four clusters of exposure were identified: no pollen and low air pollution (Cluster 1), grass pollen (Cluster 2), PM10 (Cluster 3) and birch/plane-tree pollen with high total pollen count (Cluster 4). Compared with children in Cluster 1, children in Cluster 2 had significantly lower FEV1 and FVC levels, and children from Cluster 3 had higher FeNO levels. For FEV1 and FVC, the associations appeared stronger in children with current asthma. Additional analysis suggested a joint effect of grass pollen and air pollution on lung function.Conclusion Daily ambient chemical and biological air quality could adversely influence lung function in children.Data are available upon reasonable request. ER -