TY - JOUR T1 - Novel recessive locus for body mass index in childhood asthma JF - Thorax JO - Thorax DO - 10.1136/thoraxjnl-2020-215742 SP - thoraxjnl-2020-215742 AU - Sanghun Lee AU - Jessica Lasky-Su AU - Sungho Won AU - Cecelia Laurie AU - Juan Carlos Celedón AU - Christoph Lange AU - Scott Weiss AU - Julian Hecker Y1 - 2021/04/22 UR - http://thorax.bmj.com/content/early/2021/05/13/thoraxjnl-2020-215742.abstract N2 - Most genome-wide association studies of obesity and body mass index (BMI) have so far assumed an additive mode of inheritance in their analysis, although association testing supports a recessive effect for some of the established loci, for example, rs1421085 in FTO. In two whole-genome sequencing (WGS) studies of children with asthma and their parents (892 Costa Rican trios and 286 North American trios), we discovered an association between a locus (rs9292139) in LOC102724122 and BMI that reaches genome-wide significance under a recessive model in the combined analysis. As the association does not achieve significance under an additive model, our finding illustrates the benefits of the recessive model in WGS analyses. ER -