@article {Leethoraxjnl-2020-215742, author = {Sanghun Lee and Jessica Lasky-Su and Sungho Won and Cecelia Laurie and Juan Carlos Celed{\'o}n and Christoph Lange and Scott Weiss and Julian Hecker}, title = {Novel recessive locus for body mass index in childhood asthma}, elocation-id = {thoraxjnl-2020-215742}, year = {2021}, doi = {10.1136/thoraxjnl-2020-215742}, publisher = {BMJ Publishing Group Ltd}, abstract = {Most genome-wide association studies of obesity and body mass index (BMI) have so far assumed an additive mode of inheritance in their analysis, although association testing supports a recessive effect for some of the established loci, for example, rs1421085 in FTO. In two whole-genome sequencing (WGS) studies of children with asthma and their parents (892 Costa Rican trios and 286 North American trios), we discovered an association between a locus (rs9292139) in LOC102724122 and BMI that reaches genome-wide significance under a recessive model in the combined analysis. As the association does not achieve significance under an additive model, our finding illustrates the benefits of the recessive model in WGS analyses.}, issn = {0040-6376}, URL = {https://thorax.bmj.com/content/early/2021/05/13/thoraxjnl-2020-215742}, eprint = {https://thorax.bmj.com/content/early/2021/05/13/thoraxjnl-2020-215742.full.pdf}, journal = {Thorax} }