RT Journal Article
SR Electronic
T1 Lesson of the month: novel method to quantify neutrophil uptake in early lung cancer using SPECT-CT
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 1020
OP 1023
DO 10.1136/thoraxjnl-2020-214642
VO 75
IS 11
A1 Neda Farahi
A1 Daniel Gillett
A1 Mark Southwood
A1 Doris Rassl
A1 Nicola Tregay
A1 Uta Hill
A1 Stephen Denis Preston
A1 Chrystalla Loutsios
A1 Laurence Si Chong Lok
A1 Sarah Heard
A1 John Buscombe
A1 Robert Campbell Rintoul
A1 A Michael Peters
A1 Charlotte Summers
A1 Edwin R Chilvers
YR 2020
UL http://thorax.bmj.com/content/75/11/1020.abstract
AB Neutrophils play an important role in the lung tumour microenvironment. We hypothesised that radiolabelled neutrophils coupled to single-photon emission CT (SPECT) may non-invasively quantify neutrophil uptake in tumours from patients with non-small cell lung cancer. We demonstrated increased uptake of radiolabelled neutrophils from the blood into tumours compared with non-specific uptake using radiolabelled transferrin. Moreover, indium-111-neutrophil activity in the tumour biopsies also correlated with myeloperoxidase (MPO)-positive neutrophils. Our data support the utility of imaging with In-111-labelled neutrophils and SPECT-CT to quantify neutrophil uptake in lung cancer.