RT Journal Article
SR Electronic
T1 Pregnancy in lymphangioleiomyomatosis: clinical and lung function outcomes in two national cohorts
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 904
OP 907
DO 10.1136/thoraxjnl-2020-214987
VO 75
IS 10
A1 Taveira-DaSilva, Angelo M
A1 Johnson, Simon R
A1 Julien-Williams, Patricia
A1 Johnson, Jan
A1 Stylianou, Mario
A1 Moss, Joel
YR 2020
UL http://thorax.bmj.com/content/75/10/904.abstract
AB Pregnancy in women with lymphangioleiomyomatosis (LAM) has been associated with increased complications and worsening lung function although objective data to advise patients are not available. We assessed lung function and CT scans before and after pregnancy in 16 women with LAM. During the pregnancy, pneumothorax was frequent and mean forced expiratory volume in 1 s (FEV1) fell from 77%±19% prepregnancy to 64%±25% predicted and DLCO from 66±26 to 57±26 (both p<0.01). After pregnancy, rates of FEV1 decline were high and 10 patients required sirolimus. Women with LAM, especially with moderate or advanced disease should be counselled regarding adverse events and loss of lung function during the pregnancy.