RT Journal Article
SR Electronic
T1 Extracorporeal CO<sub>2</sub> removal (ECCO<sub>2</sub>R) in patients with stable COPD with chronic hypercapnia: a proof-of-concept study
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 897
OP 900
DO 10.1136/thoraxjnl-2020-214744
VO 75
IS 10
A1 Pisani, Lara
A1 Nava, Stefano
A1 Desiderio, Emilia
A1 Polverino, Mario
A1 Tonetti, Tommaso
A1 Ranieri, V Marco
YR 2020
UL http://thorax.bmj.com/content/75/10/897.abstract
AB Domiciliary non-invasive ventilation (NIV) effectively reduces arterial carbon dioxide pressure (PaCO2) in patients with stable hypercapnic chronic obstructive pulmonary disease, but a consistent percentage of them may remain hypercapnic. We hypothesised that extracorporeal CO2 removal (ECCO2R) may lower their PaCO2. Ten patients hypercapnic despite ≥6 months of NIV underwent a 24-hour trial of ECCO2R. Six patients completed the ECCO2R-trial with a PaCO2 drop ranging between 23% and 47%. Time to return to baseline after interruption ranged 48–96 hours. In four patients, mechanical events led to ECCO2R premature interruption, despite a decreased in PaCO2. This time window ‘free’ from hypercapnia might allow to propose the concept of ‘CO2 dialysis’.