@article {Pisani897, author = {Lara Pisani and Stefano Nava and Emilia Desiderio and Mario Polverino and Tommaso Tonetti and V Marco Ranieri}, title = {Extracorporeal CO2 removal (ECCO2R) in patients with stable COPD with chronic hypercapnia: a proof-of-concept study}, volume = {75}, number = {10}, pages = {897--900}, year = {2020}, doi = {10.1136/thoraxjnl-2020-214744}, publisher = {BMJ Publishing Group Ltd}, abstract = {Domiciliary non-invasive ventilation (NIV) effectively reduces arterial carbon dioxide pressure (PaCO2) in patients with stable hypercapnic chronic obstructive pulmonary disease, but a consistent percentage of them may remain hypercapnic. We hypothesised that extracorporeal CO2 removal (ECCO2R) may lower their PaCO2. Ten patients hypercapnic despite >=6 months of NIV underwent a 24-hour trial of ECCO2R. Six patients completed the ECCO2R-trial with a PaCO2 drop ranging between 23\% and 47\%. Time to return to baseline after interruption ranged 48{\textendash}96 hours. In four patients, mechanical events led to ECCO2R premature interruption, despite a decreased in PaCO2. This time window {\textquoteleft}free{\textquoteright} from hypercapnia might allow to propose the concept of {\textquoteleft}CO2 dialysis{\textquoteright}.}, issn = {0040-6376}, URL = {https://thorax.bmj.com/content/75/10/897}, eprint = {https://thorax.bmj.com/content/75/10/897.full.pdf}, journal = {Thorax} }