TY - JOUR T1 - Lung-targeting lentiviral vector for passive immunisation against influenza JF - Thorax JO - Thorax DO - 10.1136/thoraxjnl-2020-214656 SP - thoraxjnl-2020-214656 AU - Tiong Kit Tan AU - Toby P E Gamlen AU - Pramila Rijal AU - Alain R Townsend AU - Deborah R Gill AU - Stephen C Hyde Y1 - 2020/09/03 UR - http://thorax.bmj.com/content/early/2020/09/03/thoraxjnl-2020-214656.abstract N2 - When recombinant simian immunodeficiency virus (SIV) is pseudotyped with the F and HN glycoproteins from murine respiratory Sendai virus (rSIV.F/HN), it provides efficient lung cell targeting and lifelong transgene expression in the murine airways. We have shown that a single dose of rSIV.F/HN can direct stable expression of neutralising antibody against influenza in the murine airways and systemic circulation, and protects mice against two different influenza strains in lethal challenge experiments. These data suggest that rSIV.F/HN could be used as a vector for passive immunisation against influenza and other respiratory pathogens. ER -