PT  - JOURNAL ARTICLE
AU  - Jennifer M Felton
AU  - David A Dorward
AU  - Jennifer A Cartwright
AU  - Philippe MD Potey
AU  - Calum T Robb
AU  - Jingang Gui
AU  - Ruth W Craig
AU  - Jürgen Schwarze
AU  - Christopher Haslett
AU  - Rodger Duffin
AU  - Ian Dransfield
AU  - Christopher D Lucas
AU  - Adriano G Rossi
TI  - Mcl-1 protects eosinophils from apoptosis and exacerbates allergic airway inflammation
AID  - 10.1136/thoraxjnl-2019-213204
DP  - 2020 Jul 01
TA  - Thorax
PG  - 600--605
VI  - 75
IP  - 7
4099  - http://thorax.bmj.com/content/75/7/600.short
4100  - http://thorax.bmj.com/content/75/7/600.full
SO  - Thorax2020 Jul 01; 75
AB  - Eosinophils are key effector cells in allergic diseases. Here we investigated Mcl-1 (an anti-apoptotic protein) in experimental allergic airway inflammation using transgenic overexpressing human Mcl-1 mice (hMcl-1) and reducing Mcl-1 by a cyclin-dependent kinase inhibitor. Overexpression of Mcl-1 exacerbated allergic airway inflammation, with increased bronchoalveolar lavage fluid cellularity, eosinophil numbers and total protein, and an increase in airway mucus production. Eosinophil apoptosis was suppressed by Mcl-1 overexpression, with this resistance to apoptosis attenuated by cyclin-dependent kinase inhibition which also rescued Mcl-1-exacerbated allergic airway inflammation. We propose that targeting Mcl-1 may be beneficial in treatment of allergic airway disease.