@article {Stockthoraxjnl-2020-214579, author = {Carmel J Stock and Caterina Conti and {\'A}ngeles Montero-Fernandez and Gaetano Caramori and Philip L Molyneaux and Peter M George and Maria Kokosi and Vaslis Kouranos and Toby M Maher and Felix Chua and Alexandra Rice and Christopher P Denton and Andrew G Nicholson and Athol Wells and Piersante Sestini and Elisabetta A Renzoni}, title = {Interaction between the promoter MUC5B polymorphism and mucin expression: is there a difference according to ILD subtype?}, elocation-id = {thoraxjnl-2020-214579}, year = {2020}, doi = {10.1136/thoraxjnl-2020-214579}, publisher = {BMJ Publishing Group Ltd}, abstract = {The MUC5B promoter variant rs35705950 is associated with idiopathic pulmonary fibrosis (IPF). MUC5B glycoprotein is overexpressed in IPF lungs. We examined immunohistochemical expression of MUC5B in different interstitial lung disease patterns according to rs35705950 T-allele carriage. We observed increased expression of MUC5B in T-allele carriers in both distal airways and honeycomb cysts in patients with IPF (n=23), but no difference in MUC5B expression according to T-carrier status in the distal airways of patients with idiopathic non-specific interstitial pneumonitis (n=17), in scleroderma-associated non-specific interstitial pneumonitis (n=15) or in control lungs (n=20), suggesting that tissue overexpression in MUC5B rs35705950 T-carriers is specific to IPF.}, issn = {0040-6376}, URL = {https://thorax.bmj.com/content/early/2020/06/24/thoraxjnl-2020-214579}, eprint = {https://thorax.bmj.com/content/early/2020/06/24/thoraxjnl-2020-214579.full.pdf}, journal = {Thorax} }