RT Journal Article
SR Electronic
T1 Acute exacerbations of chronic obstructive pulmonary disease: in search of diagnostic biomarkers and treatable traits
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 520
OP 527
DO 10.1136/thoraxjnl-2019-214484
VO 75
IS 6
A1 Alexander G Mathioudakis
A1 Wim Janssens
A1 Pradeesh Sivapalan
A1 Aran Singanayagam
A1 Mark T Dransfield
A1 Jens-Ulrik Stæhr Jensen
A1 Jørgen Vestbo
YR 2020
UL http://thorax.bmj.com/content/75/6/520.abstract
AB Acute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with a significant mortality, health and economic burden. Their diagnosis, assessment and management remain suboptimal and unchanged for decades. Recent clinical and translational studies revealed that the significant heterogeneity in mechanisms and outcomes of exacerbations could be resolved by grouping them etiologically. This is anticipated to lead to a better understanding of the biological processes that underlie each type of exacerbation and to allow the introduction of precision medicine interventions that could improve outcomes. This review summarises novel data on the diagnosis, phenotyping, targeted treatment and prevention of COPD exacerbations.