PT  - JOURNAL ARTICLE
AU  - Gabriela P Peralta
AU  - Alessandro Marcon
AU  - Anne-Elie Carsin
AU  - Michael J Abramson
AU  - Simone Accordini
AU  - André FS Amaral
AU  - Josep M Antó
AU  - Gayan Bowatte
AU  - Peter Burney
AU  - Angelo Corsico
AU  - Pascal Demoly
AU  - Shyamali Dharmage
AU  - Bertil Forsberg
AU  - Elaine Fuertes
AU  - Vanessa Garcia-Larsen
AU  - Thorarinn Gíslason
AU  - José-Antonio Gullón
AU  - Joachim Heinrich
AU  - Mathias Holm
AU  - Deborah L Jarvis
AU  - Christer Janson
AU  - Rain Jogi
AU  - Ane Johannessen
AU  - Bénédicte Leynaert
AU  - Jesús Martínez-Moratalla Rovira
AU  - Dennis Nowak
AU  - Nicole Probst-Hensch
AU  - Chantal Raherison
AU  - José-Luis Sánchez-Ramos
AU  - Torben Sigsgaard
AU  - Valérie Siroux
AU  - Giulia Squillacioti
AU  - Isabel Urrutia
AU  - Joost Weyler
AU  - Jan-Paul Zock
AU  - Judith Garcia-Aymerich
TI  - Body mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS study
AID  - 10.1136/thoraxjnl-2019-213880
DP  - 2020 Apr 01
TA  - Thorax
PG  - 313--320
VI  - 75
IP  - 4
4099  - http://thorax.bmj.com/content/75/4/313.short
4100  - http://thorax.bmj.com/content/75/4/313.full
SO  - Thorax2020 Apr 01; 75
AB  - Background Previous studies have reported an association between weight increase and excess lung function decline in young adults followed for short periods. We aimed to estimate lung function trajectories during adulthood from 20-year weight change profiles using data from the population-based European Community Respiratory Health Survey (ECRHS).Methods We included 3673 participants recruited at age 20–44 years with repeated measurements of weight and lung function (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1)) in three study waves (1991–93, 1999–2003, 2010–14) until they were 39–67 years of age. We classified subjects into weight change profiles according to baseline body mass index (BMI) categories and weight change over 20 years. We estimated trajectories of lung function over time as a function of weight change profiles using population-averaged generalised estimating equations.Results In individuals with normal BMI, overweight and obesity at baseline, moderate (0.25–1 kg/year) and high weight gain (>1 kg/year) during follow-up were associated with accelerated FVC and FEV1 declines. Compared with participants with baseline normal BMI and stable weight (±0.25 kg/year), obese individuals with high weight gain during follow-up had −1011 mL (95% CI −1.259 to −763) lower estimated FVC at 65 years despite similar estimated FVC levels at 25 years. Obese individuals at baseline who lost weight (<−0.25 kg/year) exhibited an attenuation of FVC and FEV1 declines. We found no association between weight change profiles and FEV1/FVC decline.Conclusion Moderate and high weight gain over 20 years was associated with accelerated lung function decline, while weight loss was related to its attenuation. Control of weight gain is important for maintaining good lung function in adult life.