RT Journal Article
SR Electronic
T1 Altered relaxation times in MRI indicate bronchopulmonary dysplasia
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 184
OP 187
DO 10.1136/thoraxjnl-2018-212384
VO 75
IS 2
A1 Förster, Kai
A1 Ertl-Wagner, Birgit
A1 Ehrhardt, Harald
A1 Busen, Hannah
A1 Sass, Steffen
A1 Pomschar, Andreas
A1 Naehrlich, Lutz
A1 Schulze, Andreas
A1 Flemmer, Andreas W
A1 Hübener, Christoph
A1 Eickelberg, Oliver
A1 Theis, Fabian
A1 Dietrich, Olaf
A1 Hilgendorff, Anne
YR 2020
UL http://thorax.bmj.com/content/75/2/184.abstract
AB We developed a MRI protocol using transverse (T2) and longitudinal (T1) mapping sequences to characterise lung structural changes in preterm infants with bronchopulmonary dysplasia (BPD). We prospectively enrolled 61 infants to perform 3-Tesla MRI of the lung in quiet sleep. Statistical analysis was performed using logistic Group Lasso regression and logistic regression. Increased lung T2 relaxation time and decreased lung T1 relaxation time indicated BPD yielding an area under the curve (AUC) of 0.80. Results were confirmed in an independent study cohort (AUC 0.75) and mirrored by lung function testing, indicating the high potential for MRI in future BPD diagnostics.Trial registration DRKS00004600.