%0 Journal Article %A John Busby %A Cecile T J Holweg %A Akiko Chai %A Peter Bradding %A Fang Cai %A Rekha Chaudhuri %A Adel H Mansur %A James Laurence Lordan %A John G Matthews %A Andrew Menzies-Gow %A Robert Niven %A Tracy Staton %A Liam G Heaney %T Change in type-2 biomarkers and related cytokines with prednisolone in uncontrolled severe oral corticosteroid dependent asthmatics: an interventional open-label study %D 2019 %R 10.1136/thoraxjnl-2018-212709 %J Thorax %P 806-809 %V 74 %N 8 %X Type-2 biomarkers and related cytokines (IL-5, IL-13), lung function and asthma symptoms were measured in 44 poorly-controlled severe oral corticosteroid (OCS)-dependent asthmatics for up to 88 days after a 7-day prednisolone boost (0.5 mg/kg). High-dose OCS reduced median blood eosinophils (−60 cells/µl; 95% CI −140 to 10), periostin (−8.4 ng/mL; −11.6 to –2.8), FeNO (−19.0 ppb; −28.5 to –4.0), IL-5 (−0.17 pg/mL; −0.28 to –0.08) and IL-13 (−0.15 pg/mL; −0.27 to –0.03). There were small improvements in mean FEV1 (0.16 L; 0.05 to 0.27) and (Asthma Control Questionnaire) ACQ-7 score (0.3; 0.0 to 0.7). Study measures returned to baseline 1-month postintervention. Following rescue OCS, 1 month is sufficient before using type-2 biomarkers to guide long-term treatment.Trial registration number NCT01948401. %U https://thorax.bmj.com/content/thoraxjnl/74/8/806.full.pdf