PT  - JOURNAL ARTICLE
AU  - Guibert, Nicolas
AU  - Didier, Alain
AU  - Moreno, Benjamin
AU  - Lepage, Benoit
AU  - Leyx, Pierre
AU  - Plat, Gavin
AU  - Mhanna, Laurent
AU  - Murris, Marlene
AU  - Mazières, Julien
AU  - Hermant, Christophe
TI  - Treatment of complex airway stenoses using patient-specific 3D-engineered stents: a proof-of-concept study
AID  - 10.1136/thoraxjnl-2018-212732
DP  - 2019 Aug 01
TA  - Thorax
PG  - 810--813
VI  - 74
IP  - 8
4099  - http://thorax.bmj.com/content/74/8/810.short
4100  - http://thorax.bmj.com/content/74/8/810.full
SO  - Thorax2019 Aug 01; 74
AB  - Anatomically complex airway stenosis (ACAS) represents a challenging situation in which commercially available stents often result in migration or granulation tissue reaction due to poor congruence. This proof-of-concept clinical trial investigated the feasibility and safety of computer-assisted designed (CAD) and manufactured personalised three-dimensional (3D) stents in patients with ACAS from various origins. After CAD of a virtual stent from a CT scan, a mould is manufactured using a 3D computer numerical control machine, from which a medical-grade silicone stent is made. Complication rate, dyspnoea, quality of life and respiratory function were followed after implantation. The congruence of the stent was assessed peroperatively and at 1 week postimplantation (CT scan). The stent could be implanted in all 10 patients. The 3-month complication rate was 40%, including one benign mucus plugging, one stent removal due to intense cough and two stent migrations. 9 of 10 stents showed great congruence within the airways, and 8 of 10 induced significant improvement in dyspnoea, quality of life and respiratory function. These promising outcomes in highly complex situations support further investigation on the subject, including technological improvements.​Trial registration number NCT02889029.