RT Journal Article
SR Electronic
T1 Altered relaxation times in MRI indicate bronchopulmonary dysplasia
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP thoraxjnl-2018-212384
DO 10.1136/thoraxjnl-2018-212384
A1 Kai Förster
A1 Birgit Ertl-Wagner
A1 Harald Ehrhardt
A1 Hannah Busen
A1 Steffen Sass
A1 Andreas Pomschar
A1 Lutz Naehrlich
A1 Andreas Schulze
A1 Andreas W Flemmer
A1 Christoph Hübener
A1 Oliver Eickelberg
A1 Fabian Theis
A1 Olaf Dietrich
A1 Anne Hilgendorff
YR 2019
UL http://thorax.bmj.com/content/early/2019/04/30/thoraxjnl-2018-212384.abstract
AB We developed a MRI protocol using transverse (T2) and longitudinal (T1) mapping sequences to characterise lung structural changes in preterm infants with bronchopulmonary dysplasia (BPD). We prospectively enrolled 61 infants to perform 3-Tesla MRI of the lung in quiet sleep. Statistical analysis was performed using logistic Group Lasso regression and logistic regression. Increased lung T2 relaxation time and decreased lung T1 relaxation time indicated BPD yielding an area under the curve (AUC) of 0.80. Results were confirmed in an independent study cohort (AUC 0.75) and mirrored by lung function testing, indicating the high potential for MRI in future BPD diagnostics.Trial registration DRKS00004600.