PT  - JOURNAL ARTICLE
AU  - Kai Förster
AU  - Birgit Ertl-Wagner
AU  - Harald Ehrhardt
AU  - Hannah Busen
AU  - Steffen Sass
AU  - Andreas Pomschar
AU  - Lutz Naehrlich
AU  - Andreas Schulze
AU  - Andreas W Flemmer
AU  - Christoph Hübener
AU  - Oliver Eickelberg
AU  - Fabian Theis
AU  - Olaf Dietrich
AU  - Anne Hilgendorff
TI  - Altered relaxation times in MRI indicate bronchopulmonary dysplasia
AID  - 10.1136/thoraxjnl-2018-212384
DP  - 2019 Apr 30
TA  - Thorax
PG  - thoraxjnl-2018-212384
4099  - http://thorax.bmj.com/content/early/2019/04/30/thoraxjnl-2018-212384.short
4100  - http://thorax.bmj.com/content/early/2019/04/30/thoraxjnl-2018-212384.full
AB  - We developed a MRI protocol using transverse (T2) and longitudinal (T1) mapping sequences to characterise lung structural changes in preterm infants with bronchopulmonary dysplasia (BPD). We prospectively enrolled 61 infants to perform 3-Tesla MRI of the lung in quiet sleep. Statistical analysis was performed using logistic Group Lasso regression and logistic regression. Increased lung T2 relaxation time and decreased lung T1 relaxation time indicated BPD yielding an area under the curve (AUC) of 0.80. Results were confirmed in an independent study cohort (AUC 0.75) and mirrored by lung function testing, indicating the high potential for MRI in future BPD diagnostics.Trial registration DRKS00004600.