RT Journal Article
SR Electronic
T1 Automated O<sub>2</sub> titration improves exercise capacity in patients with hypercapnic chronic obstructive pulmonary disease: a randomised controlled cross-over trial
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 298
OP 301
DO 10.1136/thoraxjnl-2018-211967
VO 74
IS 3
A1 Isabelle Vivodtzev
A1 Erwan L’Her
A1 Gabrielle Vottero
A1 Claire Yankoff
A1 Renaud Tamisier
A1 François Maltais
A1 François Lellouche
A1 Jean-Louis Pépin
YR 2019
UL http://thorax.bmj.com/content/74/3/298.abstract
AB Automatically titrated O2 flows (FreeO2) was compared with constant O2 flow on exercise capacity, O2 saturation and risk of hyperoxia-related hypercapnia in patients with severe COPD with baseline hypercapnia and long-term oxygen therapy (LTOT). Twelve patients were enrolled in a randomised double-blind cross-over study to perform exercise with either FreeO2 or constant flow. Endurance time (primary outcome) and SpO2 were both significantly improved with FreeO2compared with constant flow (p&lt;0.04), although pCO2 was similar in both conditions. Automated titration of O2 significantly and clinically improved endurance walking time in patients with severe COPD receiving LTOT, without worsening of pCO2.Trial registration number Results , NCT01575327