RT Journal Article SR Electronic T1 CT-derived muscle remodelling after bronchoscopic lung volume reduction in advanced emphysema JF Thorax JO Thorax FD BMJ Publishing Group Ltd and British Thoracic Society SP 206 OP 207 DO 10.1136/thoraxjnl-2018-211931 VO 74 IS 2 A1 Karin J C Sanders A1 Karin Klooster A1 Lowie E G W Vanfleteren A1 Dirk-Jan Slebos A1 Annemie M W J Schols YR 2019 UL http://thorax.bmj.com/content/74/2/206.abstract AB Muscle wasting frequently occurs in severe emphysema. Improving respiratory mechanics by bronchoscopic lung volume reduction using endobronchial valves (EBV) might prevent further loss or even increase in muscle mass. CT-derived skeletal muscle mass gain was observed in 39/49 patients 6 months after EBV. Multiple linear regression showed that gain in muscle (β=2.4; 95% CI 0.2 to 4.6; p=0.036) and intramuscular fat (β=3.1; 95% CI 0.2 to 5.9; p=0.035) is associated with improved 6 min walk distance independent of the change in residual volume. Skeletal muscle remodelling associates with improved exercise capacity after EBV, independent of hyperinflation reduction.Trial registration number Clinical trial registered with the Dutch trial register www.trialregister.nl (NTR2876), Results.