TY - JOUR T1 - CT-derived muscle remodelling after bronchoscopic lung volume reduction in advanced emphysema JF - Thorax JO - Thorax SP - 206 LP - 207 DO - 10.1136/thoraxjnl-2018-211931 VL - 74 IS - 2 AU - Karin J C Sanders AU - Karin Klooster AU - Lowie E G W Vanfleteren AU - Dirk-Jan Slebos AU - Annemie M W J Schols Y1 - 2019/02/01 UR - http://thorax.bmj.com/content/74/2/206.abstract N2 - Muscle wasting frequently occurs in severe emphysema. Improving respiratory mechanics by bronchoscopic lung volume reduction using endobronchial valves (EBV) might prevent further loss or even increase in muscle mass. CT-derived skeletal muscle mass gain was observed in 39/49 patients 6 months after EBV. Multiple linear regression showed that gain in muscle (β=2.4; 95% CI 0.2 to 4.6; p=0.036) and intramuscular fat (β=3.1; 95% CI 0.2 to 5.9; p=0.035) is associated with improved 6 min walk distance independent of the change in residual volume. Skeletal muscle remodelling associates with improved exercise capacity after EBV, independent of hyperinflation reduction.Trial registration number Clinical trial registered with the Dutch trial register www.trialregister.nl (NTR2876), Results. ER -