PT  - JOURNAL ARTICLE
AU  - Maxime Patout
AU  - Gill Arbane
AU  - Antoine Cuvelier
AU  - Jean Francois Muir
AU  - Nicholas Hart
AU  - Patrick Brian Murphy
TI  - Polysomnography versus limited respiratory monitoring and nurse-led titration to optimise non-invasive ventilation set-up: a pilot randomised clinical trial
AID  - 10.1136/thoraxjnl-2017-211067
DP  - 2019 Jan 01
TA  - Thorax
PG  - 83--86
VI  - 74
IP  - 1
4099  - http://thorax.bmj.com/content/74/1/83.short
4100  - http://thorax.bmj.com/content/74/1/83.full
SO  - Thorax2019 Jan 01; 74
AB  - Polysomnography (PSG) is recommended for non-invasive ventilation (NIV) set-up in patients with chronic respiratory failure. In this pilot randomised clinical trial, we compared the physiological effectiveness of NIV set-up guided by PSG to limited respiratory monitoring (LRM) and nurse-led titration in patients with COPD–obstructive sleep apnoea (OSA) overlap. The principal outcome of interest was change in daytime arterial partial pressure of carbon dioxide (PaCO2) at 3 months. Fourteen patients with daytime PaCO2 >6 kPa and body mass index >30 kg/m2 were recruited. At 3 months, PaCO2 was reduced by −0.88 kPa (95% CI −1.52 to −0.24 kPa) in the LRM group and by −0.36 kPa (95% CI −0.96 to 0.24 kPa) in the PSG group. These pilot data provide support to undertake a clinical trial investigating the clinical effectiveness of attended limited respiratory monitoring and PSG to establish NIV in patients with COPD–OSA overlap.Trial number Results, NCT02444806.