RT Journal Article SR Electronic T1 Alternaria sensitisation at age 6 years is associated with subsequent airway hyper-responsiveness in non-asthmatics JF Thorax JO Thorax FD BMJ Publishing Group Ltd and British Thoracic Society SP 1170 OP 1173 DO 10.1136/thoraxjnl-2017-210325 VO 73 IS 12 A1 Hiranrattana, Anunya A1 Stern, Debra A A1 Guerra, Stefano A1 Halonen, Marilyn A1 Wright, Anne L A1 Daines, Michael A1 Martinez, Fernando D A1 Morgan, Wayne J YR 2018 UL http://thorax.bmj.com/content/73/12/1170.abstract AB In the non-selected birth cohort Tucson Children’s Respiratory Study, early sensitisation to Alternaria was associated with increased airway hyper-responsiveness (AHR) into adult life among non-asthmatics. The increase in AHR was of a similar magnitude to that seen for Alternaria sensitised asthmatics and was primarily evident among those who were overweight or obese. In contrast, there was no significant association between early sensitisation to aeroallergens other than Alternaria and AHR among non-asthmatics. Why this group of Alternaria sensitised individuals without asthma demonstrated increased AHR of a magnitude similar to asthmatics is unknown and requires further investigation.