PT  - JOURNAL ARTICLE
AU  - Hiranrattana, Anunya
AU  - Stern, Debra A
AU  - Guerra, Stefano
AU  - Halonen, Marilyn
AU  - Wright, Anne L
AU  - Daines, Michael
AU  - Martinez, Fernando D
AU  - Morgan, Wayne J
TI  - <em>Alternaria</em> sensitisation at age 6 years is associated with subsequent airway hyper-responsiveness in non-asthmatics
AID  - 10.1136/thoraxjnl-2017-210325
DP  - 2018 Dec 01
TA  - Thorax
PG  - 1170--1173
VI  - 73
IP  - 12
4099  - http://thorax.bmj.com/content/73/12/1170.short
4100  - http://thorax.bmj.com/content/73/12/1170.full
SO  - Thorax2018 Dec 01; 73
AB  - In the non-selected birth cohort Tucson Children’s Respiratory Study, early sensitisation to Alternaria was associated with increased airway hyper-responsiveness (AHR) into adult life among non-asthmatics. The increase in AHR was of a similar magnitude to that seen for Alternaria sensitised asthmatics and was primarily evident among those who were overweight or obese. In contrast, there was no significant association between early sensitisation to aeroallergens other than Alternaria and AHR among non-asthmatics. Why this group of Alternaria sensitised individuals without asthma demonstrated increased AHR of a magnitude similar to asthmatics is unknown and requires further investigation.