PT  - JOURNAL ARTICLE
AU  - Samuel Y Ash
AU  - Rola Harmouche
AU  - Rachel K Putman
AU  - James C Ross
AU  - Fernando J Martinez
AU  - Augustine M Choi
AU  - Russell P Bowler
AU  - Elizabeth A Regan
AU  - Jeffrey L Curtis
AU  - MeiLan K Han
AU  - Richard C Boucher
AU  - Wanda K O’Neal
AU  - Hiroto Hatabu
AU  - David A Lynch
AU  - Ivan O Rosas
AU  - Gary M Hunninghake
AU  - Raul San Jose Estepar
AU  - George R Washko
ED  - ,
TI  - Association between acute respiratory disease events and the <em>MUC5B</em> promoter polymorphism in smokers
AID  - 10.1136/thoraxjnl-2017-211208
DP  - 2018 Nov 01
TA  - Thorax
PG  - 1071--1074
VI  - 73
IP  - 11
4099  - http://thorax.bmj.com/content/73/11/1071.short
4100  - http://thorax.bmj.com/content/73/11/1071.full
SO  - Thorax2018 Nov 01; 73
AB  - A single-nucleotide polymorphism (rs35705950) in the mucin 5B (MUC5B) gene promoter is associated with pulmonary fibrosis and interstitial features on chest CT but may also have beneficial effects. In non-Hispanic whites in the COPDGene cohort with interstitial features (n=454), the MUC5B promoter polymorphism was associated with a 61% lower odds of a prospectively reported acute respiratory disease event (P=0.001), a longer time-to-first event (HR=0.57; P=0.006) and 40% fewer events (P=0.016). The MUC5B promoter polymorphism may have a beneficial effect on the risk of acute respiratory disease events in smokers with interstitial CT features.